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While derived from an epidemiologic review rather than a randomized controlled trial (RCT), that is a troubling statistic, Because the psychedelics LSD and psilocybin useful for microdosing have even stronger binding affinity for 5HT2B receptor than MDMA and its Energetic metabolite MDA (+LSD Ki = thirty nM, psilocin Ki= three. = 0.05 threshold